P. I.
Research Associates
Graduate Students
Ying Zhou
Christopher Thibodeaux
Jessica White
Hak Joong Kim
Eita Sasaki
Wei-Chen Chang
Sei Hyun Choi
Mel Cheng-Hao Liu
Grace He Sun
Anthony Romo
Chia-I Lin
ke-Yi Lin
Meilan Wu
Eta Isiorho
Post Docs
Group Pictures


Chris Thibodeaux





Degree: B.S., Louisiana State University

Entered Group: Fall, 2003

Research Projects: Kinetic and Mechanistic Studies of Enzyme Catalysis:
1-Aminocyclopropane-1-carboxylate Deaminase, Cyclopropane Fatty Acid Synthase, Isopentenyl Pyrophosphate Isomerase Type II, and PARP-1



Group Publications:

Melancon C. E., III; Thiibodeaux, C. J.; Liu, H.-w. "Glyco-stripping and Glyco-swapping." JCS Chem. Biol. 2006, 1, 499-504.

Thiibodeaux, C. J.; Liu, H.-w. "Manipulating Nature's Sugar Biosynthetic Machineries for Glycodiversification of Macrolides." Pure Appl. Chem.. 2007, 79, 785-799.

Thiibodeaux, C. J.; Melancon C. E., III; Liu, H.-w. "Sugar Biosynthetic Enzymes and Natural Product Glycodiversification." Nature. 2007, 446, 1008-1016.

Kittleman, W.; Thiibodeaux, C. J.; Liu, Y.-n.; Zhang, H.; Liu, H.-w. "Characterization and Mechanistic Studies of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Staphylococcus aureus." Biochemistry. 2007, 46, 8401-8413.

Mansoorabadi, S. O.; Thiibodeaux, C. J.; Liu, H.-w. "The Diverse Roles of Flavin Coenzymes - Nature's Most Versatile Thespians." J. Org. Chem.. 2007, 72, 6329-6342.

Thibodeaux, C.; Liu, H.-w.; Thorson, J. S. "Complimentary Routes to Natural Product Glycodiversification: Pathway Engineering and Glycorandomization." In Comprehensive Glycoscience (Kamerling, J. P, Boons, G-J., Lee, Y., Suzuki, A., Taniguchi, N., Voragen, A. G. J., Eds.) Elservier: Amsterdam; 2007, Vol 3, p 373-396.

Thibodeaux, C. J.; Mansoorabadi, S. O.; Kittleman, W.; Chang, W.-c.; Liu, H.-w. "Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase (IDI-2) from Staphylococcus aureus." Biochemistry. 2008, 47, 2547-2558.

Thibodeaux, C. J.; Melancon, C. E., III.; Liu, H.-w. "Natural Product Sugar Biosynthesis and Enzymatic Glycodiversification." Angew. Chem. Int. Ed., 2008, 47, 9814-9859.

White, J. A.; Thibodeaux, C. J.; Liu, H.-w. "Enzymatic Synthesis of TDP-sugars." Meth. Enzymol. 2009, 459, 521-544.

Thibodeaux, C. J.; Liu, H.-w. "Unraveling the Mechanisms of Isoprenoid Biosynthetic Enzymes: Mechanistic Studies of the Early Stage Enzymes." Chimia 2009, 63, 334-339.