Yung-nan Liu

Degree: B.S., Tunghai University, Taiwan, ROC
Ph.D., Mt. Sinai Medical School, New York, NY

Postdoc Assoc: NCI Postdoctoral Fellow, Harvard Medical School, Boston, MA

Entered Group: May, 2002

Research Projects: Chemical Biology of Poly(ADP-ribosyl)ation,
Biochemical Studies of the Biosynthesis of Unusual Sugars



Group Publications:

Agnihotri, G.; Liu, Y.-n.; Paschal, B.; Liu, H.-w. "Identification of An Unusual [2Fe-2S]-Binding Motif in the Dehydrase Responsible for C-3 Deoxygenation in the Biosynthesis of 3,6-Dideoxyhexoses." Biochemistry 2004, 43, 14265-14274.

Takahashi, H.; Liu, Y-n.; Chen, H.; Liu, H.-w. "Biosynthesis of TDP-Mycarose: The Specificity of a Single Enzyme Governs the Outcome of the Pathway." J. Am. Chem. Soc. 2005, 127, 9340-9341.

Takahashi, H.; Liu, Y.-n.; Liu, H.-w. "A Two-Stage One-Pot Enzymatic Synthesis of TDP-L-mycarose from Thymidine and Glucose-1-phosphate." J. Am. Chem. Soc., 2006, 128, 1432-1433.

Melancon, C. E.; Hong, L.; White, J. A.; Takahashi, H.; Liu, Y.-n.; Liu, H.-w. "Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-isomerase (Tyl1a) from the TDP-D-Mycaminose Pathway of Streptomyces fradiae." Biochemistry, 2007, 46, 577-590.

Wu, Q.; Liu, Y.-n.; Chen, H.; Molitor, E. J.; Liu, H.-w. "A Retro-Evolution Study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1): Implications for C-3 Deoxygenation in the Biosynthesis of 3,6-Dideoxyhexoses." Biochemistry, 2007, 46, 3756-3767.

Kittleman, W.; Thibodeaux, C. J.; Liu, Y.-n.; Zhang, H.; Liu, H.-w. "Characterization and Mechanistic Studies of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Staphylococcus aureus." Biochemistry, 2007, 46, 8401-8413.